ChemicalBook > CAS DataBase List > Nutlin-3b

Nutlin-3b

Product Name
Nutlin-3b
CAS No.
675576-97-3
Chemical Name
Nutlin-3b
Synonyms
CS-986;Nutlin-3b;9-trioxaundecane;11-Bis(tosyloxy)-3;NUTLIN-3B;NUTLIN 3B;Nutlin-3b USP/EP/BP;(+)-NUTLIN-3;NUTLIN 3B;Nutlin-3b - Nutlin-3, (+)-;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid;4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
CBNumber
CB42624268
Molecular Formula
C30H30Cl2N4O4
Formula Weight
581.49
MOL File
675576-97-3.mol
More
Less

Nutlin-3b Property

Density 
1.36
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO
form 
crystalline solid
pka
14.35±0.20(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
5mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
10mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
10009816
Product name
(+)-Nutlin-3
Purity
≥98%
Packaging
25mg
Price
$536
Updated
2024/03/01
TRC
Product number
N925530
Product name
Nutlin3b
Packaging
10mg
Price
$250
Updated
2021/12/16
More
Less

Nutlin-3b Chemical Properties,Usage,Production

Description

(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (–)-nutlin-3 . It inhibits the interaction between p53 and Mdm2 150-fold less potently than (–)-nutlin-3 with an IC50 value of 13.6 μM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (–)-nutlin-3 in cancer cells.

Uses

Nutlin 3b is a small molecule MDM2 antagonist.

Definition

ChEBI: Nutlin-3 is a Nutlin and a piperazinone. It has a role as an anticoronaviral agent.

References

[1] tovar c, rosinski j, filipovic z, higgins b, kolinsky k, hilton h, zhao x, vu bt, qing w, packman k, myklebost o, heimbrook dc, vassilev lt. small-molecule mdm2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. proc natl acad sci u s a. 2006 feb 7;103(6):1888-93.
[2] cao c, shinohara et, subhawong tk, geng l, kim kw, albert jm, hallahan de, lu b. radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2. mol cancer ther. 2006 feb;5(2):411-7.

Nutlin-3b Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Nutlin-3b Suppliers

China 76 France 1 The Netherlands 1 United States 15 Global 93
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58
More
Less

View Lastest Price from Nutlin-3b manufacturers

Career Henan Chemical Co
Product
Nutlin-3b 675576-97-3
Price
US $1.00/g
Min. Order
200KG
Purity
99%
Supply Ability
2tons
Release date
2019-12-19

675576-97-3, Nutlin-3bRelated Search:

NUTLIN-3 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Imatinib mesylate Tozasertib Nutlin-3 Nutlin 3a ABT 263

  • Nutlin-3b
  • 4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
  • 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
  • 4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone Nutlin 3b
  • NUTLIN-3B;NUTLIN 3B
  • 4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid
  • CS-986
  • 4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
  • Nutlin-3b - Nutlin-3, (+)-
  • (+)-NUTLIN-3;NUTLIN 3B
  • Nutlin-3b USP/EP/BP
  • 11-Bis(tosyloxy)-3
  • 9-trioxaundecane
  • 675576-97-3
  • 677576-97-3
  • Inhibitors